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Diabetes Pathophysiology

The video demonstrates the mechanism of GLP-1 and insulin in a simplified, fun-to-learn manner for clinicians.

References:

  1. DeFronzo RA. Lilly Lecture. The triumvirate: ß-cell, muscle, liver: a collusion responsible for NIDDM. Diabetes. 1988;37(6):667-687.
  2. DeFronzo RA. Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes. 2009;58(4):773-795.
  3. DeFronzo RA. Overview of newer agents: where treatment is going. Am J Med. 2010;123(3 suppl):S38-S48.
  4. Baggio LL, Drucker DJ. Biology of incretins: GLP-1 and GIP. Gastroenterology. 2007;132(6):2131-2157.
  5. Kalra S. Recent advances in pathophysiology of diabetes: beyond the dirty dozen. J Pak Med Assoc. 2013;62(2):277-280.