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GLP-1 in Type 2 Diabetes: A Primer

This video presentation describes the physiologic role of native glucagon-like peptide-1 (GLP-1) and the impact of incretin impairment in type 2 diabetes
Ralph DeFronzo, MD
Professor of Medicine and Chief of the Diabetes Division at the University of Texas Health Science Center
San Antonio, Texas
Ralph DeFronzo, MD

References:

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  2. DeFonzo RA. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes. 2009; 58(4): 773-795.
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  8. Zander M, Madsbad S, Madsen JL, Hoist JJ. Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study. Lancet. 2002; 359(9309):824-830.
  9. Højberg PV, Vilsbøll T, Rabøl R, et al. Four weeks of near-normalisation of blood glucose improves the insulin response to glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes. Diabetologia. 2009; 52(2):199-207.
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