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Native GLP-1: Impact on the Incretin Effect

In this video, Dr. Ralph DeFronzo describes the essential role of incretin hormones GLP-1 and GIP in the maintenance of normal glucose homeostasis and the regulation of insulin secretion. He discusses impairment of the incretin effect in patients with type 2 diabetes and shows data related to the benefit of GLP-1 administration.
Ralph DeFronzo, MD
Professor of Medicine and Chief of the Diabetes Division at the University of Texas Health Science Center
San Antonio, Texas
Ralph DeFronzo, MD

References:

  1. Nauck M, Stöckmann F, Ebert R, Creutzfeldt W. Reduced incretin effect in type 2 (non-insulin-dependent) diabetes. Diabetologia. 1986;29(1):46–52.
  2. Campbell JE, Drucker DJ. Pharmacology, physiology, and mechanisms of incretin hormone action. Cell Metab. 2013;17(6):819-837.
  3. DeFronzo RA. Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes. 2009;58(4):773-795.
  4. Vilsbøll T, Krarup T, Madsbad S, Holst JJ. Defective amplification of the late phase insulin response to glucose by GIP in obese type II diabetic patients. Diabetologia. 2002;45(8):1111–1119.