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The Ominous Octet: Core Defects in Type 2 Diabetes

Dr Ralph DeFronzo discusses eight core defects implicated in the pathogenesis of type 2 diabetes as described during his “Ominous Octet” Banting lecture presented in 2008. He also reviews the role of GLP-1 in many of the core defects present in type 2 diabetes.
Ralph DeFronzo, MD
Professor of Medicine and Chief of the Diabetes Division at the University of Texas Health Science Center
San Antonio, Texas
Ralph DeFronzo, MD


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